Table 3

KEGG analysis on gene lists for Foxl2-null or Wnt4-null fetal ovaries.

Foxl2 null-depleted

Foxl2 null-enriched


Pathway

N

Proportion

N

Proportion

p-value

Ubiquitin mediated proteolysis

    (42)

    (0,06)

11

0,02

0,00003

Insulin signaling pathway

    (35)

    (0,05)

8

0,01

0,00004

ErbB signaling pathway

    (28)

    (0,04)

6

0,01

0,00018

MAPK signaling pathway

    (58)

    (0,09)

26

0,04

0,00067

Axon guidance

    (40)

    (0,06)

15

0,02

0,00132

Prostate cancer

    (22)

    (0,03)

5

0,01

0,00146

Colorectal cancer

    (27)

    (0,04)

8

0,01

0,00179

Long-term potentiation

    (19)

    (0,03)

4

0,01

0,00252

Adherens junction

    (24)

    (0,04)

7

0,01

0,0032

Glioma

    (19)

    (0,03)

5

0,01

0,00644

Apoptosis

    (15)

    (0,02)

3

0,00

0,0074

Wnt signaling pathway

    (41)

    (0,06)

19

0,03

0,00773

Alanine and aspartate metabolism

0

0,00

    (8)

    (0,01)

0,00318

One carbon pool by folate

2

0,00

    (13)

    (0,02)

0,00333

Glyoxylate and dicarboxylate metabolism

0

0,00

    (9)

    (0,01)

0,00154

Glycolysis/Gluconeogenesis

3

0,00

    (19)

    (0,03)

0,00035

Oxidative phosphorylation

7

0,01

    (33)

    (0,05)

0,00001

Ribosome (protein synthesis)

3

0,00

    (79)

    (0,13)

0

Wnt4 null-depleted

Wnt4 null-enriched

Pathway

N

Proportion

N

Proportion

p-value

Ribosome (protein synthesis)

    (55)

    (0,09)

7

0,01

0

Oxidative phosphorylation

    (51)

    (0,08)

7

0,01

0

Glycolysis/Gluconeogenesis

    (18)

    (0,03)

3

0,00

0,00008

Fructose and mannose metabolism

    (15)

    (0,02)

4

0,01

0,00194

Calcium signaling pathway

16

0,03

    (45)

    (0,06)

0,00548

Neuroactive ligand-receptor interaction

19

0,03

    (52)

    (0,07)

0,00441

Leukocyte transendothelial migration

9

0,01

    (33)

    (0,04)

0,00396

Cell adhesion molecules (CAMs)

7

0,01

    (31)

    (0,04)

0,00141

Cytokine-cytokine receptor interaction

18

0,03

    (54)

    (0,07)

0,00135

Natural killer cell mediated cytotoxicity

9

0,01

    (36)

    (0,05)

0,00115

Complement and coagulation cascades

2

0,00

    (19)

    (0,02)

0,00131

ECM-receptor interaction

9

0,01

    (37)

    (0,05)

0,00076

Focal adhesion

23

0,04

    (70)

    (0,09)

0,00014


Columns from left to right: name of the pathway, number and proportion of genes that are down- or up-regulated in the respective knockout model, and corresponding p-value. All the pathways with FDR < 10% are shown. Underlines indicate pathways that are enriched in the corresponding columns.

Garcia-Ortiz et al. BMC Developmental Biology 2009 9:36   doi:10.1186/1471-213X-9-36

Open Data