Figure 3.

Muscle weight, fiber number, and fiber type in skeletal muscle-specific Gdf11 mutant mice in a Mstn wild-type or null background. (A) Weight of pectoralis, triceps, quadriceps, gastrocnemius/plantaris, and tibialis anterior muscles (n = 7–12). (B) Number of total, IIA, IID/X, and IIB fibers in the EDL muscle (n = 3–4). EDL muscles had on average less than 4 type I fibers in all genotypes so type I data are not shown. (C) Number of total, type I, IIA, IID/X, and IIB fibers in the soleus muscle (n = 3–5). Skeletal muscle-specific Gdf11 deletion had no effect on muscle mass, fiber number, or fiber type unlike Mstn deletion (*P < 0.05, ^†P < 0.01, ^‡P < 0.001). Data are mean ± s.e.