Table 1

Embryos with mutant genotype Tie2·Cre+/-Srff/f die by E14.5
Age
 Cre+/Srff/f
 Cre+/Srff/+
 Cre-/Srff/f
 Cre-/Srff/+
E9.5
 7 (0)
 5
 10
 16
E10.5
 12 (0)
 14 (1)
 15
 26
E11.5
 19 (1)
 29 (2)
 7
 17
E12.5
 24 (11)
 21
 17
 7
E13.5
 21 (19)
 15
 14 (2)
 16
E14.5
 10 (8)
 3
 3
 4
E18.5
 2 (2)
 4
 2
 5
Neonate
 0
 18
 20
 13

Genotypic analysis of mouse embryos generated by crossing Tie2Cre+/-Srff/+ male mice with Srff/f female mice. Numbers represent total embryos of each genotype; numbers in parentheses indicate mutant phenotype and grossly necrotic embryos. The conditional loss of Srf gene function in endothelial cells resulted in embryonic death by E14.5; no animals with mutant genotype were detected during late gestational age or at birth.

Holtz and Misra BMC Developmental Biology 2008 8:65   doi:10.1186/1471-213X-8-65