Table 3

Life span extension by BD is additive with known chemosensory pathways.

Cohort

n

Mean Survival

Median Survival

% extension of Median

p-value


N2 CF

164

24.2 ± 0.4

22.5

-

-

N2 BD

153

32.2 ± 0.7

34.0

51

1.7 × 10-17

che-3(p801) CF

147

34.3 ± 0.8

34.0

51

2.0 × 10-21

che-3(p801) BD

168

44.2 ± 1.3

44.0

96

2.6 × 10-28


N2 CF

70

22.1 ± 0.6

21.0

-

-

N2 BD

112

34.3 ± 0.7

35.0

67

6.0 × 10-22

che-11(e1810) CF

45

34.7 ± 1.3

35.0

67

8.6 × 10-15

che-11(e1810) BD

44

45.9 ± 2.1

44.0

110

2.3 × 10-16


N2 CF

117

24.3 ± 0.5

24.0

-

-

N2 BD

74

36.5 ± 0.8

37.0

54

3.7 × 10-25

daf-10 (e1387) CF

76

32.7 ± 1.3

34.0

42

4.1 × 10-07

daf-10 (e1387) BD

56

43.1 ± 2.0

40.0

67

1.7 × 10-17


N2 CF

119

22.9 ± 0.4

22.0

-

-

N2 BD

131

32.1 ± 0.8

34.0

55

1.1 × 10-16

osm-3(p802) CF

94

32.4 ± 0.9

32.0

45

5.9 × 10-18

osm-3(p802) BD

64

42.5 ± 1.8

43.0

95

4.6 × 10-18


N2 CF

117

24.3 ± 0.5

24.0

-

-

N2 BD

74

36.5 ± 0.8

37.0

54

3.7 × 10-23

tax-4(p678) CF

113

36.9 ± 0.7

37.0

54

1.9 × 10-26

tax-4(p678)) BD

155

53.6 ± 0.9

57.0

138

6.0 × 10-41


Life span was measured for a subset of chemosensory mutants, compared to N2, on plates with food (control fed, CF) or on plates without food (bacterial deprivation, BD). The number of animals (n), mean survival (± standard error, SE), median survival, percent extension of the median, and p-values are given for each strain and condition. Data shown here are pooled from a minimum of two independent trials. P-values were calculated by the Wilcoxon Rank-Sum test using the MATLAB 'ranksum' function.

Smith et al. BMC Developmental Biology 2008 8:49   doi:10.1186/1471-213X-8-49

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