Table 2

Effects of mutations on the morphology of the pharyngeal NSM neurons.

Genotype

Normal (%)

Short dorsal process (%)

Short sub-ventral process (%)

Long dorsal process (%)

Dorsal process absent (%)

Sub-ventral process absent (%)

Anterior guided axons (%)

Absent Minor process (%)

Others* (%)

N

Controls

wild-type

95

4

1

185

unc-30

93

4

3

1

196

unc-46

91

6

1

1

1

328

Growth cone-defective mutants

unc-14

72

11

4

1

10

202

unc-41

96

3

1

172

unc-51

23

22

16

29

1

1

9

226

unc-73

30

20

6

4

27

10

3

283

unc-76

35

37

2

1

25

1

272

unc-115

87

1

2

10

1

225

unc-119

29

41

4

1

22

4

269

Positional cue and cue interpretation mutants.

fax-1

84

8

6

2

198

kal-1

61

10

15

1

6

5

2

219

max-1

95

1

1

3

228

mob-20

100

194

sax-3

26

1

3

2

12

37

19

210

slt-1

41

16

22

7

4

6

4

247

smp-2

64

18

6

5

5

3

168

unc-5

40

26

6

3

13

11

1

181

unc-6

40

24

1

2

32

1

307

unc-34

9

7

3

77

1

1

3

204

unc-40

39

3

5

12

26

8

4

4

229

unc-69

26

38

8

28

1

184

unc-129

57

15

9

7

6

6

198

vab-1

87

7

3

1

1

1

181

vab-8

95

2

1

2

214

wrk-1

83

10

3

2

2

189

zag-1

83

2

4

4

5

2

1

200

zig-4

92

4

4

100

Extracellular matrix protein

mec-1

75

4

8

9

4

253

sax-7

32

1

4

37

7

30

1

145

sdn-1

41

11

5

4

6

32

1

254

unc-23

68

3

2

5

2

1

20

237

unc-52

64

8

7

3

2

16

213

unc-61

75

5

16

3

1

172

unc-112

75

6

9

7

3

1

340

Synapse Function mutants

syg-1

43

26

1

24

5

1

183

unc-101

0

4

2

7

3

5

100

13

223

unc-104

94

5

1

174

Genes important for proper function of NSM

mod-5

73

17

7

3

1

168

tph-1

94

1

3

2

168

Pharyngeal morphology mutants

mnm-5

79

2

1

8

1

11

267

pha-2

4

1

1

21

45

27

141

*The category "others" reflect specific phenotypes encountered for individual mutants, as follows:

mnm-5: misplaced cell bodies, complete loss of guidance.

pha-2: misplaced cell bodies; sub-branching of the misguided branches; minor process absent; multiple branching.

sax-3: thickened endings of axons; misplaced cell bodies; multiple branching; all branches are anterior misguided; sub-branching of the misguided branches; minor process absent.

unc-23: thickened endings of axons.

unc-51: milder defects similar to unc-73 (ectopic branching).

unc-52: thickened endings of axons.

unc-73: thickened endings of axons; multiple branching from cell bodies.

unc-101: thickened endings of axons; multiple branching from cell bodies.

Axäng et al. BMC Developmental Biology 2008 8:38   doi:10.1186/1471-213X-8-38