Figure 6.

Model of teneurin signalling. This model describes how an intracellular domain (ICD) could be generated from a transmembrane protein and transported to the nucleus. This process takes place only in specific cells and tissues where the anti-ICD labeled nuclei. 1) A first protease sheds the extracellular domain (ECD) of teneurins. 2) The remainder of teneurin-1 can now become a substrate for an intramembrane protease. 3) The ICD is released. 4) The soluble ICD translocates to the nucleus via nuclear localization signal (NLS). EGF, EGF-like repeats; YD, YD-repeats. Red arrows indicate postulated cleavage sites and the yellow spheres proteins interacting with teneurin-1 ICD in the nucleus.