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Expression of BLIMP1, PRMT5 and dimethylated histone H4/H2A in normal and neoplastic testicular tissues |
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| BLIMP1 |
PRMT5 |
H4R3me2s/H2Ame2s |
|
|
|
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| Normal fetal testis |
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| Gonocytes |
+++ (n) |
+++ (n,c) |
+++ (n) |
| Pre-spermatogonia |
- |
- |
|
| Normal adult testis (N = 18) |
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| Spermatogonia |
- |
- |
++ (n) |
| Pachytene spermatocytes |
- |
+ (n) |
- |
| Round spermatids |
+ (n,c) |
++ (n) |
++ (n) |
| Elongated spermatids |
- |
- |
- |
| Testicular germ cell tumors |
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| IGCNU (N = 15) |
+++ (n) 85–100% |
+++ (c) 75–95% |
+++ (n) 90–100% |
| Seminoma (N = 20) |
++ (n) 10–75% |
++ (n+c) 30–85% |
++ (n) 20–80% |
| Embryonal carcinoma (N = 15) |
+/-(c)* 15–80% |
++ (c) 15–80% |
(+)* |
| Teratoma (N = 5) |
+ (n, c) |
+ (n, c) |
+ (n) |
| Chorioncarcinoma (N = 3) |
+ (c) |
- |
- |
|
N, number of cases; n, nuclear staining; c, cytoplasmatic staining + weak; ++ moderate; +++, strong expression; -, no expression detectable *, only single tumor cells were detected as positive. | |||
Eckert et al. BMC Developmental Biology 2008 8:106 doi:10.1186/1471-213X-8-106 |
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