  Research articleAn evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10James R Dutton1,4 1Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK 2Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA 3Max-Planck Institute for Immunobiology, Freiberg, Germany 4Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA
BMC Developmental Biology 2008, 8:105doi:10.1186/1471-213X-8-105
Additional filesAdditional file 1: TRANSFAC analysis of mouse, chicken and zebrafish sox10 intron 1. The sequence of intron 1 for each species was submitted to the TRANSFAC transcription factor binding site database. Shown, in each case, is the 3'-most region of intron 1, with the last two nucleotides of the intron noted in bold italics. Sequences that are highly conserved in mammals are underlined in the mouse intron 1 sequence, and the individual transcription factor binding sites are highlighted in colour. Note the conservation of the order of predictions for (5' to 3') NFKappaB, TCF, FoxD3, and Sox binding-site consensus sequences. Furthermore, with one exception (FoxD3 and Sox consensus sequences in chicken), the orientation of each predicted binding site is also conserved among the three species. Format: PDF Size: 303KB Download file This file can be viewed with: Adobe Acrobat Reader |
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