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Numbers and health status of pre-implantation embryos collected following chronic and acute maternal TCDD exposure |
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| Treatment (# animals) |
Average # embryos/animal (range) |
Average # blastomere/embryo (range) |
# Normal embryos/total embryos (%) |
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| Chronic exposure (compaction) |
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| Control (3) |
13.0 (12–14) |
12.5 (7–18) |
31/39 (79.5) |
| 50 ng/kg/wk TCDD (3) |
13.7 (13–15) |
11.3 (4–17) |
15/41 (36.6)* |
| Acute exposure (compaction) |
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| Control (3) |
13.3 (13–14) |
9.5 (3–16) |
32/40 (80.0) |
| 50 ng/kg TCDD (5) |
12.0 (11–13) |
9.5 (3–16) |
31/60 (51.7)* |
| 1 μg/kg TCDD (6) |
9.2 (3–13) |
10.1 (6–16) |
21/46 (45.7)* |
| Acute exposure (blastocyst) |
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| Control (6) |
10.5 (9–12) |
31.9 (13–52) |
48/63 (76.2) |
| 50 ng/kg TCDD (3) |
9.7 (9–10) |
32.1 (8–58) |
17/29 (58.6) |
| 1 μg/kg TCDD (5) |
9.0 (9–12) |
37.5 (8–63) |
20/45 (45.5)* |
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*Significantly different from control | |||
Hutt et al. BMC Developmental Biology 2008 8:1 doi:10.1186/1471-213X-8-1 |
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