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Open AccessResearch article

The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo

Karla J Hutt1 email, Zhanquan Shi2 email, David F Albertini1,3 email and Brian K Petroff2 email

1  The Center for Reproductive Sciences, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA

2  Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA

3  Marine Biological Laboratory, Woods Hole, MA 02543, USA

author email corresponding author email

BMC Developmental Biology 2008, 8:1doi:10.1186/1471-213X-8-1

Published: 2 January 2008

Additional files


Additional file 1:

Control compaction stage pre-implantation embryo. Z-axis step through of control pre-implantation embryo. Green: tubulin; red: f-actin; white: DNA.

Format: MOV Size: 9.8MB Download file

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Additional file 2:

Chronically treated compaction stage pre-implantation embryo. Z-axis step through of a pre-implantation embryo following chronic maternal exposure to TCDD (50 ng/kg/wk). This is the same pre-implantation embryo as shown in Fig. 1M–P. Green: tubulin; red: f-actin; white: DNA.

Format: MOV Size: 9MB Download file

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Additional file 3:

Nuclear profile of compaction stage pre-implantation embryos from control animal. 3D rotation illustrating the nuclear profile of a control pre-implantation embryo.

Format: MOV Size: 5.4MB Download file

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Additional file 4:

Nuclear profile of compaction stage pre-implantation embryos from chronically exposed animal. 3D rotation illustrating the nuclear profile of a pre-implantation embryo following chronic maternal exposure to TCDD (50 ng/kg/wk).

Format: MOV Size: 5.4MB Download file

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Additional file 5:

Control blastocyst. 3D rotation illustrating the nuclear and f-actin profiles of a control blastocyst. This is the same embryo as shown in Fig. 3A and 3B. Red: f-actin; white: DNA.

Format: MOV Size: 5.4MB Download file

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Additional file 6:

Acute 50 ng/kg blastocyst. 3D rotation illustrating the nuclear and f-actin profiles of a blastocyst following acute exposure to 50 ng/kg TCDD. Red: f-actin; white: DNA.

Format: MOV Size: 5.4MB Download file

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Additional file 7:

Acute 1 μg/kg blastocyst. 3D rotation illustrating the nuclear and f-actin profiles of a blastocyst following acute exposure to 1 μg/kg TCDD. Red: f-actin; white: DNA.

Format: MOV Size: 5.4MB Download file

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