Research article
The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo
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* Corresponding author: Brian K Petroff bpetroff@kumc.edu
1 The Center for Reproductive Sciences, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
2 Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
3 Marine Biological Laboratory, Woods Hole, MA 02543, USA
BMC Developmental Biology 2008, 8:1 doi:10.1186/1471-213X-8-1
Published: 2 January 2008Additional files
Control compaction stage pre-implantation embryo. Z-axis step through of control pre-implantation embryo. Green: tubulin; red: f-actin; white: DNA.
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Chronically treated compaction stage pre-implantation embryo. Z-axis step through of a pre-implantation embryo following chronic maternal exposure to TCDD (50 ng/kg/wk). This is the same pre-implantation embryo as shown in Fig. 1M–P. Green: tubulin; red: f-actin; white: DNA.
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Nuclear profile of compaction stage pre-implantation embryos from control animal. 3D rotation illustrating the nuclear profile of a control pre-implantation embryo.
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Nuclear profile of compaction stage pre-implantation embryos from chronically exposed animal. 3D rotation illustrating the nuclear profile of a pre-implantation embryo following chronic maternal exposure to TCDD (50 ng/kg/wk).
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Control blastocyst. 3D rotation illustrating the nuclear and f-actin profiles of a control blastocyst. This is the same embryo as shown in Fig. 3A and 3B. Red: f-actin; white: DNA.
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Acute 50 ng/kg blastocyst. 3D rotation illustrating the nuclear and f-actin profiles of a blastocyst following acute exposure to 50 ng/kg TCDD. Red: f-actin; white: DNA.
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Acute 1 μg/kg blastocyst. 3D rotation illustrating the nuclear and f-actin profiles of a blastocyst following acute exposure to 1 μg/kg TCDD. Red: f-actin; white: DNA.
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