Table 1

Summary of ocular phenotypes

Ocular phenotype

Examined Mutant

No. with ocular phenotype/No. of examined mutants

Penetrance (%)


Coloboma (by E18.5)

Rybp heterozygous (+/-) mice

5/15

33

Coloboma, lens defects (By E14.5)

Chimeric mice Rybp-/- <->

6 exencephalic/19

32

Rybp+/+

3 non exencephalic/19

16

Cataract (by 3 month)

ROSA26-Rybp/EGFP; αA-crystallin/Cre Tg/+ mice

44/75

59

Neovascularization (by 3 month)

ROSA26-Rybp/EGFP; β-Actin/Cre Tg/+ mice

30/87

35

Neovascularization (by 3 month)

ROSA26-Rybp/EGFP; β-Actin/Cre Tg/Tg mice

30/38

80

Coloboma, irregular retinal folds, anterior chamber defects (by P7)

ROSA26-Rybp/EGFP; β-Actin/Cre Tg/Tg mice

11/38

29


Pirity et al. BMC Developmental Biology 2007 7:39   doi:10.1186/1471-213X-7-39

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