Table 3

Genes showing 2-fold or greater changes in hypertrophic zone

Gene Name

Gene Description

Fold Change (CNP/Control)


Cxcl14

chemokine (C-X-C motif) ligand 14

7.15

Ptgs2

prostaglandin-endoperoxide synthase 2

6.77

Grem1

cysteine knot superfamily 1, BMP antagonist 1

6.47

Fbxo32

F-box only protein 32

5.87

Glipr1

GLI pathogenesis-related 1 (glioma)

5.22

Gdf5

growth differentiation factor 5

4.93

Nox4

NADPH oxidase 4

3.78

Ebi2

Epstein-Barr virus induced gene 2

3.78

Evi1

ecotropic viral integration site 1

3.50

Prnd

prion protein dublet

3.43

Acdc

adipocyte complement related protein

3.42

Nes

nestin

3.33

Tnnt3

troponin T3, skeletal, fast

3.29

Nox4

NADPH oxidase 4

3.27

Rbp1

retinol binding protein 1, cellular

3.19

Hist1h2bc

histone 1, H2bp

3.16

Inhbb

inhibin beta-B

3.12

Sox17

SRY-box containing gene 17

3.10

Rnf125

ring finger protein 125

3.08

Fabp4

fatty acid binding protein 4, adipocyte

3.07

C1ql3

C1q-like 3

3.03

Rbpms

RNA binding protein gene with multiple splicing

3.02

Nrarp

Notch-regulated ankyrin repeat protein

3.02

Mmrn2

multimerin 2

3.00

Cldn5

claudin 5

3.00

Cd44

CD44 antigen

2.99

Klhl4

kelch-like 4 (Drosophila)

2.98

Pscd4

pleckstrin homology, Sec7 and coiled/coil domains 4

2.90

Ptprc

protein tyrosine phosphatase, receptor type, C

2.86

Rasgrp1

RAS guanyl releasing protein 1

2.85

Ptger2

prostaglandin E receptor 2 (subtype EP2)

2.84

Ctla2b

trophoblast specific protein beta

2.84

Copg2as2

coatomer protein complex, subunit gamma 2, antisense 2

2.82

Ian1

immune associated nucleotide 1

2.82

Pmaip1

phorbol-12-myristate-13-acetate-induced protein 1

2.77

Gpihbp1

GPI-anchored HDL-binding protein 1

2.73

Cdh5

cadherin 5

2.69

Niban

niban protein

2.67

Ptpn3

protein tyrosine phosphatase, non-receptor type 3

2.67

Slc26a7

solute carrier family 26, member 7

2.67

Tm6sf1

transmembrane 6 superfamily member 1

2.65

Pkp2

plakophilin 2

2.65

Bcl2a1a

B-cell leukemia/lymphoma 2 related protein A1a

2.63

Prss8

protease, serine, 8 (prostasin)

2.61

Fads3

fatty acid desaturase 3

2.60

Runx1

runt related transcription factor 1

2.56

Abcc9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

2.56

Nr2f1

nuclear receptor subfamily 2, group F, member 1

2.55

Hbb-y

hemoglobin Y, beta-like embryonic chain

2.52

Akr1b8

aldo-keto reductase family 1, member B8

2.51

Siat8f

sialyltransferase 8 (alpha-2, 8-sialyltransferase) F

2.51

Sfpi1

SFFV proviral integration 1

2.51

Zbtb33

zinc finger and BTB domain containing 33

2.49

Gdpd1

glycerophosphodiester phosphodiesterase domain containing 1

2.46

Clecsf6

C-type lectin, superfamily member 6

2.46

Pstpip1

proline-serine-threonine phosphatase-interacting protein 1

2.45

Esam1

endothelial cell-specific adhesion molecule

2.44

Cdh13

cadherin 13

2.43

Hist2h3c2

histone 2, H2aa1

2.43

Sfrp2

secreted frizzled-related sequence protein 2

2.40

Cables1

Cdk5 and Abl enzyme substrate 1

2.39

Ednrb

endothelin receptor type B

2.39

Eltd1

EGF, latrophilin seven transmembrane domain containing 1

2.38

Calcrl

calcitonin receptor-like

2.38

Ctla2b

trophoblast specific protein beta

2.38

Ian1

immune associated nucleotide 1

2.36

Sox18

SRY-box containing gene 18

2.36

Plce1

phospholipase C, epsilon 1

2.33

Il13ra1

interleukin 13 receptor, alpha 1

2.33

Cd38

CD38 antigen

2.32

Ncf4

neutrophil cytosolic factor 4

2.30

Rgs4

regulator of G-protein signaling 4

2.30

Ptpn8

protein tyrosine phosphatase, non-receptor type 8

2.29

Inhba

inhibin beta-A

2.29

Alcam

activated leukocyte cell adhesion molecule

2.27

Pira1

paired-Ig-like receptor A1

2.27

Cav2

caveolin 2

2.27

Cxcr4

chemokine (C-X-C motif) receptor 4

2.26

Sh3bp5

calpain 7

2.26

Mfap3l

microfibrillar-associated protein 3-like

2.26

Dscr1

Down syndrome critical region homolog 1 (human)

2.25

Mcam

melanoma cell adhesion molecule

2.24

Ms4a6d

membrane-spanning 4-domains, subfamily A, member 6D

2.24

Cd34

CD34 antigen

2.24

Zfp42

zinc finger protein 42

2.23

Kcne3

potassium voltage-gated channel, Isk-related subfamily, gene 3

2.22

Ivns1abp

influenza virus NS1A binding protein

2.22

Cd84

CD84 antigen

2.22

Kdr

kinase insert domain protein receptor

2.21

Clca5

chloride channel calcium activated 5

2.20

Itga9

integrin alpha 9

2.19

Prkch

protein kinase C, eta

2.19

Tex15

testis expressed gene 15

2.18

Plac8

placenta-specific 8

2.17

Ebf3

early B-cell factor 3

2.16

Lcp2

lymphocyte cytosolic protein 2

2.16

Mcoln3

mucolipin 3

2.15

Sh3glb1

SH3-domain GRB2-like B1 (endophilin)

2.15

Ugt1a2

UDP glycosyltransferase 1 family, polypeptide A6

2.15

Egfl7

EGF-like domain 7

2.15

Icam2

intercellular adhesion molecule 2

2.15

Six1

sine oculis-related homeobox 1 homolog (Drosophila)

2.14

Chst7

carbohydrate (N-acetylglucosamino) sulfotransferase 7

2.13

Evi2a

ecotropic viral integration site 2a

2.12

Myct1

myc target 1

2.12

Pde4b

phosphodiesterase 4B, cAMP specific

2.12

Adamts1

a disintegrin-like & metalloprotease with thrombospondin type 1

2.10

Snx10

sorting nexin 10

2.10

Rac2

RAS-related C3 botulinum substrate 2

2.09

Siat8d

sialyltransferase 8 (alpha-2, 8-sialyltransferase) D

2.08

Dsg2

desmoglein 2

2.07

F11r

F11 receptor

2.06

Lrrc33

leucine rich repeat containing 33

2.06

Ian9

Similar to hypothetical protein (LOC243374), mRNA

2.06

Slc30a1

solute carrier family 30 (zinc transporter), member 1

2.05

Kcnj8

potassium inwardly-rectifying channel, subfamily J, member 8

2.05

Cotl1

coactosin-like 1 (Dictyostelium)

2.04

Ptx3

pentaxin related gene

2.04

Ctla2b

trophoblast specific protein beta

2.03

Sipa1

signal-induced proliferation associated gene 1

2.03

Rgs5

regulator of G-protein signaling 5

2.03

Itgax

integrin alpha X

2.01

Car2

carbonic anhydrase 2

2.01

Serpind1

serine (or cysteine) proteinase inhibitor, clade D, member 1

2.01

Cadps2

Ca2+-dependent activator protein for secretion 2

2.00

Il1rl2

interleukin 1 receptor-like 2

2.00

Lemd1

LEM domain containing 1

0.06

Gzme

granzyme E

0.14

Plekha7

pleckstrin homology domain containing, family A member 7

0.14

Chad

chondroadherin

0.15

Cd28

CD28 antigen

0.17

Sep-04

septin 4

0.19

Pltp

phospholipid transfer protein

0.19

Il15

interleukin 15

0.20

Ttll3

tubulin tyrosine ligase-like family, member 3

0.20

Syt8

synaptotagmin 8

0.20

Gpr91

G protein-coupled receptor 91

0.23

Sep-04

septin 4

0.24

Cd28

CD28 antigen

0.24

Efemp1

epidermal growth factor-containing fibulin-like ECM protein 1

0.25

Tnfsf11

tumor necrosis factor (ligand) superfamily, member 11

0.27

Tlr1

toll-like receptor 1

0.28

Trim2

tripartite motif protein 2

0.28

Vnn1

vanin 1

0.28

Tnni2

troponin I, skeletal, fast 2

0.29

Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

0.30

Fxyd2

FXYD domain-containing ion transport regulator 2

0.30

Rtn2

reticulon 2 (Z-band associated protein)

0.31

Iqgap2

IQ motif containing GTPase activating protein 2

0.31

Capn6

calpain 6

0.32

Rab27a

RAB27A, member RAS oncogene family

0.32

Aicda

activation-induced cytidine deaminase

0.33

F5

coagulation factor V

0.33

Hs6st2

heparan sulfate 6-O-sulfotransferase 2

0.33

Cklfsf8

chemokine-like factor super family 8

0.33

Nrk

Nik related kinase

0.33

Gprasp2

G protein-coupled receptor associated sorting protein 2

0.33

Car8

carbonic anhydrase 8

0.34

Prom1

prominin 1

0.34

Mgst2

microsomal glutathione S-transferase 2

0.34

Pltp

phospholipid transfer protein

0.35

Stc2

stanniocalcin 2

0.35

Lipg

lipase, endothelial

0.35

Il17d

interleukin 17D

0.36

Serpinb6b

serine (or cysteine) proteinase inhibitor, clade B, member 6b

0.36

Matn3

matrilin 3

0.37

Slc1a1

solute carrier family 1, member 1

0.37

Art3

ADP-ribosyltransferase 3

0.37

Cp

ceruloplasmin

0.37

Abi3bp

ABI gene family, member 3 (NESH) binding protein

0.37

Matn1

matrilin 1, cartilage matrix protein 1

0.38

A2m

alpha-2-macroglobulin

0.38

Usp11

ubiquitin specific protease 11

0.38

Col9a2

procollagen, type IX, alpha 2

0.39

Pik3r1

phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1

0.39

Rlbp1

retinaldehyde binding protein 1

0.39

Rnase4

ribonuclease, RNase A family 4

0.39

Col14a1

procollagen, type XIV, alpha 1

0.40

Slc19a3

solute carrier family 19 (sodium/hydrogen exchanger), member 3

0.40

Nfkbiz

NFK light polypeptide gene enhancer in B-cells inhibitor, zeta

0.40

Slco2b1

solute carrier organic anion transporter family, member 2b1

0.41

Fxyd6

FXYD domain-containing ion transport regulator 6

0.41

Egr3

early growth response 3

0.41

Usp53

ubiquitin specific peptidase 53

0.41

Serpini1

serine (or cysteine) proteinase inhibitor, clade I, member 1

0.41

Pitpnc1

phosphatidylinositol transfer protein, cytoplasmic 1

0.42

Anxa8

annexin A8

0.42

Il17b

interleukin 17B

0.43

Gpr126

G protein-coupled receptor 126

0.43

Pank1

pantothenate kinase 1

0.43

Dock9

dedicator of cytokinesis 9

0.43

Sfmbt2

Scm-like with four mbt domains 2

0.43

Enpp2

ectonucleotide pyrophosphatase/phosphodiesterase 2

0.44

Kctd4

potassium channel tetramerisation domain containing 4

0.44

Cobll1

Cobl-like 1

0.44

Scrg1

scrapie responsive gene 1

0.45

Matn3

matrilin 3

0.45

Zfpm2

zinc finger protein, multitype 2

0.45

Lims2

LIM and senescent cell antigen like domains 2

0.45

Gpr64

G protein-coupled receptor 64

0.45

Ptprz1

protein tyrosine phosphatase, receptor type Z, polypeptide 1

0.46

Hhip

Hedgehog-interacting protein

0.46

Eps8

epidermal growth factor receptor pathway substrate 8

0.46

Heph

hephaestin

0.47

Sesn1

sestrin 1

0.47

Ctf1

cardiotrophin 1

0.47

Zfp612

zinc finger protein 612

0.48

Wdr40b

WD repeat domain 40B

0.48

Dkk1

dickkopf homolog 1 (Xenopus laevis)

0.48

Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase

0.48

Ddc

dopa decarboxylase

0.48

Adam17

a disintegrin and metallopeptidase domain 17

0.48

Rdhe2

short chain dehydrogenase reductase 9

0.48

Vav3

vav 3 oncogene

0.48

Tmem56

transmembrane protein 56

0.48

Aldh1a3

aldehyde dehydrogenase family 1, subfamily A3

0.48

Zfp521

ecotropic viral integration site 3

0.48

Fbxo25

F-box only protein 25

0.49

Kitl

kit ligand

0.49

Plagl1

pleiomorphic adenoma gene-like 1

0.49

Hectd2

HECT domain containing 2

0.49

Bmper

BMP-binding endothelial regulator

0.49

Gprasp1

G protein-coupled receptor associated sorting protein 1

0.50

Gdf10

growth differentiation factor 10

0.50

Sox5

SRY-box containing gene 5

0.50


Agoston et al. BMC Developmental Biology 2007 7:18   doi:10.1186/1471-213X-7-18

Open Data