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Top ranked 73 down-regulated genes in Ipf1/Pdx1-/- vs. Ipf1/Pdx1 +/+ e10.5 dorsal pancreatic buds |
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| Genbank acc. No. |
Gene Symbol |
Gene Name |
Fold-change |
|
|
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| Extracellular matrix proteins |
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| NM_009263 |
Spp1 |
secreted phosphoprotein 1 |
-9.8 U * |
| NM_033525 |
Npnt |
Nephronectin |
-6.1 U |
| NM_145584 |
Spon1 |
spondin 1, (f-spondin) extracellular matrix protein |
-3.8 K ** |
| Transport |
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| NM_172479 |
Slc38a5 |
solute carrier family 38, member 5 |
-8.8 U |
| NM_011401 |
Slc2a3 |
solute carrier family 2 (facilitated glucose transporter), member 3 |
-2.6 K |
| NM_009593 |
Abcg1 |
ATP-binding cassette, sub-family G (WHITE), member 1 |
-2.3 U |
| Signaling |
|||
| NM_018763 |
Chst2 |
carbohydrate sulfotransferase 2 |
-4.5 U |
| XM_618828 |
Erbb3 |
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
-3.2 U * |
| NM_019946 |
Mgst1 |
microsomal glutathione S-transferase 1 |
-3.2 K * |
| NM_152815 |
Lins2 |
Lines homolog 2 (Drosophila) |
-2.4 U |
| NM_025505 |
Blzf1 |
basic leucine zipper nuclear factor |
-2.0 K |
| Transcription factors |
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| NM_013627 |
Pax6 |
paired box gene 6 |
-5.8 K * |
| NM_144955 |
Nkx6-1 |
Nkx transcription factor related, locus 1 (Drosophila) |
-4.2 U *** |
| NM_008686 |
Nfe2l1 |
nuclear factor, erythroid derived 2,-like 1 |
-2.6 U |
| NM_010938 |
Nrf1 |
nuclear respiratory factor 1 |
-2.2 U |
| Cell adhesion |
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| NM_008532 |
Tacstd1 |
tumor-associated calcium signal transducer 1 |
-3.2 U |
| NM_009864 |
Cdh1 |
cadherin 1 |
-2.6 U |
| Cell cycle |
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| NM_013928 |
Schip1 |
schwannomin interacting protein 1 |
-3.1 K+U |
| NM_007631 |
Ccnd1 |
cyclin D1 |
-2.6 U |
| DNA binding |
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| NM_198169 |
Gmeb2 |
glucocorticoid modulatory element binding protein 2 |
-2.9 U |
| NM_175074 |
Hmgn3 |
high mobility group nucleosomal binding domain 3 |
-2.4 K |
| Kinases/Phosphatases |
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| NM_152804 |
Plk2 |
polo-like kinase 2 (Drosophila) |
-2.9 K |
| NM_011950 |
Mapk13 |
mitogen activated protein kinase 13 |
-2.5 U |
| NM_008981 |
Ptprg |
protein tyrosine phosphatase, receptor type, G |
-2.4 U |
| Apoptosis |
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| NM_008410 |
Itm2b |
integral membrane protein 2B |
-2.3 U |
| Other |
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| NM_026433 |
1810057C19Rik |
RIKEN cDNA 1810057C19 gene |
-6.3 U |
| NM_153457 |
Rtn1 |
reticulon 1 |
-6.1 U * |
| NM_018737 |
Ctps2 |
cytidine 5'-triphosphate synthase 2 |
-5.9 U |
| NM_007694 |
Chgb |
chromogranin B |
-5.9 K |
| NM_026238 |
Narfl |
nuclear prelamin A recognition factor-like |
-4.9 U |
| NM_145562 |
9130213B05Rik |
RIKEN cDNA 9130213B05 gene |
-4.8 U |
| NM_011255 |
Rbp4 |
retinol binding protein 4, plasma |
-4.2 U |
| NM_178747 |
Gulo |
gulonolactone (L-) oxidase |
-4.2 U |
| NM_025429 |
Serpinb1a |
serine (or cysteine) proteinase inhibitor, clade B, member 1a |
-4.2 U |
| AI451390 |
ESTs, transcribed locus |
-4.0 U |
|
| NM_133977 |
Trf |
Transferring |
-4.0 K |
| NM_009412 |
Tpd52 |
tumor protein D52 |
-3.8 U |
| NM_016962 |
Spast |
Spastin |
-3.5 U |
| NM_015784 |
Postn |
periostin, osteoblast specific factor |
-3.3 U |
| NM_133697 |
1110003E01Rik |
RIKEN cDNA 1110003E01 gene |
-3.2 U |
| NM_145599 |
Tmem34 |
transmembrane protein 34 |
-3.1 U |
| NM_025633 |
Metapl1 |
methionine aminopeptidase-like 1 |
-3.0 U |
| XM_125538 |
Sesn1 |
Sestrin 1 |
-3.0 K |
| NM_013471 |
Anxa4 |
annexin A4 |
-3.0 K |
| NM_008188 |
Thumpd3 |
THUMP domain containing 3 |
-2.8 U |
| NM_026323 |
Wfdc2 |
WAP four-disulfide core domain 2 |
-2.7 U |
| NM_033073 |
Krt2-7 |
keratin complex 2, basic, gene 7 |
-2.7 U |
| BB529246 |
ESTs |
-2.7 K |
|
| NM_178600 |
Vkorc1 |
vitamin K epoxide reductase complex, subunit 1 |
-2.6 U |
| NM_026524 |
Mid1ip1 |
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) |
-2.6 K+U |
| NM_008792 |
Pcsk2 |
proprotein convertase subtilisin/kexin type 2 |
-2.6 K |
| NM_013778 |
Akr1c13 |
aldo-keto reductase family 1, member C13 |
-2.6 K |
| NM_011464 |
Spint2 |
serine protease inhibitor, Kunitz type 2 |
-2.5 U |
| NM_197996 |
Tspan15 |
tetraspanin 15 |
-2.5 U |
| NM_022316 |
Smoc1 |
SPARC related modular calcium binding 1 |
-2.5 U |
| NM_019972 |
Sort1 |
sortilin 1 |
-2.4 U |
| NM_176860 |
2810457I06Rik |
RIKEN cDNA 2810457I06 gene |
-2.4 U |
| XM_133714 |
4921517J23Rik |
RIKEN cDNA 4921517J23 gene |
-2.4 K |
| NM_146057 |
Dap |
death-associated protein |
-2.4 K |
| NM_013492 |
Clu |
clusterin |
-2.3 U |
| NM_198654 |
4833432M17Rik |
RIKEN cDNA 4833432M17 gene |
-2.3 U |
| NM_138651 |
Cds2 |
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 |
-2.2 U |
| NM_145991 |
Hrpt2 |
hyperparathyroidism 2 homolog (human) |
-2.2 U |
| NM_010485 |
Elavl1 |
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 |
-2.2 U |
| AI451897 |
ESTs, transcribed locus |
-2.2 U |
|
| NM_029341 |
Capsl |
calyphosine-like |
-2.2 K |
| NR_001592 |
H19 |
H19 fetal liver mRNA |
-2.1 U |
| XM_110660 |
AI427122 |
expressed sequence AI427122 |
-2.1 U |
| NM_025853 |
1700022L09Rik |
RIKEN cDNA 1700022L09 gene |
-2.1 U |
| NM_138606 |
Pim2 |
proviral integration site 2 |
-2.1 K |
| NM_031170 |
Krt2-8 |
Keratin complex 2, basic, gene 8 |
-2.0 U |
| NM_025975 |
Tcte1l |
t-complex-associated-testis-expressed 1-like |
-2.0 K |
| NM_007657 |
Cd9 |
CD9 antigen |
-2.0 K |
|
K = changes obtained from the 15 K microarray. U = changes obtained from the 21 K microarray. * = validated by qRT RT-PCR. ** = validated by qRT RT-PCR and in situ hybridization. *** = validated by qRT RT-PCR and immunohistochemistry. | |||
Svensson et al. BMC Developmental Biology 2007 7:129 doi:10.1186/1471-213X-7-129 |
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