Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death

Additional File 1:

Comparative quantification of TrkA, TrkB and TrkC expressing cells in the lumbar and thoracic DRGs between wild type and mutant E13.5 embryos. The data provided represent the comparative quantification of TrkA, TrkB or TrkC expressing cells in the lumbar (A) and thoracic (B) DRGs between wild-type and mutant E13.5 embryos. Shown are the mean numbers of neurons ± SEM per square millimeter. Statistical comparisons were made using the Mann-Whitney test; asterisks show differences that are statistically significant (*, p < 0.05)

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Additional File 2:

Reduction of the number of TrkA- and TrkC-expressing cell in Necdin mutant trigeminal ganglia. The data provided represent the density of Trk-expressing neuron in trigeminal ganglia at E13.5. Box-plots are representative of neuronal counts from five or more embryos. Significant loss of TrkA- and TrkC- and no lack of TrkB-cells number were observed. Statistical comparisons were made using the Mann-Whitney test; asterisks show differences that are statistically significant (*, p < 0.05).

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