Tramtrack (ttk) is required in follicle cells for the mitotic-to-endocycle transition. (A) Ttk1e11 mutant clones marked by loss of GFP (indicated by dashed line) show a decrease in the size of cell nuclei, marked with DAPI (red), indicating a defect in the mitotic-to-endocycle transition of those cells. (B) Quantification of the number of cells in ttk clones compared to the number in their sister clones shows that on average they are twice as large, which implies that ttk mutant cells have undergone an extra round of mitotic division (mean = 2.33, p = 0.0006). (C) ttk mutant clones show prolonged expression of mitotic markers, PH3 (C, C'), Cyc B (D, D') and Cyc A (E, E'; 25% n = 32, 60% n = 30, 50% n = 22, respectively).
Jordan et al. BMC Developmental Biology 2006 6:16 doi:10.1186/1471-213X-6-16