Hyperactivation of HSF-1 enhances dauer development in daf-2(e1370) mutant background. This interaction indicates that DAF-2 inhibits HSF-1, which in turn represses daf-7. Thus, HSF-1 links the insulin/IGF-1 and TGFβ pathways to control the developmental decision between normal reproductive growth vs. dauer larva formation. This epistasis model can explain how starvation induces, while nutrient availability suppresses, dauer development. Bars represent S.E.M. At both temperatures examined, daf-2(−) vs. daf-2(−); hsf-1(gf) comparison: p<0.001, student t-test.
Barna et al. BMC Developmental Biology 2012 12:32 doi:10.1186/1471-213X-12-32