Vestibular neurons survive in absence of a functional TrkB/PLCγ site, but nearly all die by disrupting both the TrkB/PLCγ and SHC sites. (A) Total vestibular neuron numbers at P7 in Trkb point mutants (TrkbPLC/PLC; TrkbD/D) compared to controls (TrkbWT/WT; TrkbPLC/+). Shown also is the loss of vestibular neurons in TrkbSHC/SHC point mutants and in Trkb null mice (Trkb-/-) for comparison. (B-D) Representative cresyl violet-stained horizontal sections of the central portion of the vestibular ganglion of control and point mutant (TrkbPLC/PLC; TrkbD/D) mice at P7 as indicated. ***, p < 0.0001 (ANOVA). Scale bar, 50 μm.
Sciarretta et al. BMC Developmental Biology 2010 10:103 doi:10.1186/1471-213X-10-103