Figure 1.

Vestibular neurons survive in absence of a functional TrkB/PLCγ site, but nearly all die by disrupting both the TrkB/PLCγ and SHC sites. (A) Total vestibular neuron numbers at P7 in Trkb point mutants (Trkb^PLC/PLC; Trkb^D/D) compared to controls (Trkb^WT/WT; Trkb^PLC/+). Shown also is the loss of vestibular neurons in Trkb^SHC/SHC point mutants and in Trkb null mice (Trkb^-/-) for comparison. (B-D) Representative cresyl violet-stained horizontal sections of the central portion of the vestibular ganglion of control and point mutant (Trkb^PLC/PLC; Trkb^D/D) mice at P7 as indicated. ***, p < 0.0001 (ANOVA). Scale bar, 50 μm.