Table 1

A summary of the anti-angiogenic properties of cheiradone. IC₅₀ values are The mean of three determinations.

Experiment

IC₅₀ value ± SEM (μM)

BAEC

HDMEC

VEGF-R1 binding

2.9 ± 0.031

VEGF-R2 binding

0.61 ± 0.14

VEGF induced Proliferation

7.8 ± 1.2

7.4 ± 0.74

Effect on VEGF-induced wound healing

7.1 ± 0.77

6.50 ± .0.97

Effect on VEGF-induced migration

7.5 ± 0.92

5.20 ± 0.38

Effect on VEGF-induced tube formation

7.7 ± 1.5

6.0 ± 0.38

Effect on VEGF-induced invasion

6.3 ± 0.31

8.3 ± 1.0

Toxicity MTT

NS

NS

Toxicity Caspase-3

NS

NS

• NS = Overall inhibition is less than 50% and therefore IC₅₀ values cannot be calculated.

Hussain et al. BMC Cell Biology 2008 9:7   doi:10.1186/1471-2121-9-7