Cheiradone inhibits in vivo angiogenesis in the CAM assay. (A) control, methylcellulose alone showed no evidence of angiogenesis or inflammation (B) cheiradone (10 μg) failed to induce blood vessel formation (C) VEGF, a network of new blood vessels was established (see arrow) at the point of application. (D) cheiradone (10 μg) + VEGF inhibited vessel formation. There was no evidence of an inflammatory response in any preparation. Representative photomicrographs are shown. Magnification ×50.
Hussain et al. BMC Cell Biology 2008 9:7 doi:10.1186/1471-2121-9-7