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Open Access Research article

Cell adhesion to agrin presented as a nanopatterned substrate is consistent with an interaction with the extracellular matrix and not transmembrane adhesion molecules

Tobias Wolfram12345, Joachim P Spatz123 and Robert W Burgess45*

Author Affiliations

1 Dept. New Materials and Biosystems, Max-Planck-Institute for Metals Research, Germany

2 University of Heidelberg, Stuttgart, Germany

3 Dept. of Biophysical Chemistry, University of Heidelberg, Stuttgart, Germany

4 Institute for Molecular Biophysics, Bar Harbor, ME, USA

5 The Jackson Laboratory, Bar Harbor, ME, USA

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BMC Cell Biology 2008, 9:64  doi:10.1186/1471-2121-9-64

Published: 4 December 2008

Additional files

Additional file 1:

Cell clustering on nanopatterned Agrin functionalized substrates. The tendency of cells to stick to one another rather than to widely spaced (90 and 160 nm) Agrin coated substrates is shown.

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Additional file 2:

Cell spreading on nanopatterned substrates. Cells show greater spreading on closely spaced Agrin substrates (30, 60 nm), but have rounder morphologies with less surface area in contact with 90 and 160 nm substrates.

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Open Data