Changes in gene expression resulting from PI 3-kinase inhibition. Proliferating T98G cells in serum-containing medium were treated with 50 μM LY294002 for 2, 4 or 8 hours. Microarray analyses at each timepoint were performed on 3 independent cultures compared to untreated controls. Data are presented as the number of genes that were significantly up-regulated and down-regulated at the specified time of treatment (Log2 > 0.9, p ≤ 0.01).
Terragni et al. BMC Cell Biology 2008 9:6 doi:10.1186/1471-2121-9-6