Table 1 |
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Angiogenesis-related genes modulated by CRP in HCAEC |
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|
Gene name |
Fold-increase (time) Experiment #1 |
Fold-increase (time) Experiment #2 |
Gene function |
|
|
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|
KDR/Flk-1/VEGFR2 |
1.53 (12 h) |
1.94 (24 h) |
Cell survival, proliferation and angiogenesis44 |
|
PDGF-B |
2.44 (24 h) |
3.94 (12 h) |
Proliferation and angiogenesis45 |
|
Notch1 |
3.28 (12 h) |
1.97 (12 h) |
Angiogenesis (spreading and branching)46 |
|
Notch3 |
2.03 (24 h) |
4.46 (72 h) |
Vascular cell identity and survival47,48 |
|
CYR61/CCN1 |
4.94 (72 h) |
3.91 (12 h) |
Connective tissue growth factor 49 |
|
ID1 |
2.65 (24 h) |
1.94 (12 h) |
Cell cycle and angiogenesis50 |
|
|
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PDGF, Platelet-derived growth factor; KDR: kinase-insert domain receptor; VEGFR2, vascular endothelial cell growth factor receptor-2; CYR61, Cysteine-rich angiogenic inducer 6; ID1, Inhibitor of DNA binding/differentiation-1. |
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Turu et al. BMC Cell Biology 2008 9:47 doi:10.1186/1471-2121-9-47 |
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