CRP stimulated spoke wheel blood vessel formation in the CAM assay. A, Negative control (score 0.5); B, CRPdt-treated (5 μg/ml; score 2.0); C, Positive control, FGF-2-treated (100 ng/ml) (score 3.0). Spoke wheel patterns can be seen in both CRP- and FGF-2-treated samples originating from the pellet (designated by dotted circles). Experiments were performed twice. A representative example of 5 CAM's used per experiment is shown.
Turu et al. BMC Cell Biology 2008 9:47 doi:10.1186/1471-2121-9-47