Expression of AR and β-Catenin in normal prostate tissues and tumor samples. A tissue microarray containing 9 prostate tumors and 4 normal prostate tissue samples was stained with antibodies against AR and β-Catenin. In normal prostate tissues, the low levels of AR expression, compared with the high levels in prostate cancer cells, were indicated by lack of AR staining in cells (A); β-Catenin was predominantly located at the normal cytoplasmic membrane (B). In late stage prostate cancer samples, AR was substantially overexpressed in the nuclei of the prostate cancer cells (C) where nuclear β-Catenin staining was also observed in some of these cells (D).
Schweizer et al. BMC Cell Biology 2008 9:4 doi:10.1186/1471-2121-9-4