Table 2

Mitotic kinesin disruptions in simple eukaryotes vs metazoans.

Kinesin Family

S. cerevisiae

Dictyostelium

C. elegans

Drosophila

Human


Mitotic Function

Kinesin-4 (Chromokin)

Kif8

Klp-19

Klp3A

Kif4A, Kif4B

Kinesin-5 (BimC/Eg5)

Cin8, Kip1

Kif13

BMK1

Klp61F

Eg5

Kinesin-6 (MKLP)

Kif12

Zen-4

Pavarotti

MKLP1, MKLP2

Kinesin-7 (CENP-E)

Kip2

Kif4, Kif11

CENP-E Meta

CENP-E

Kinesin- 8 (Kip3)

Kip3

Kif10

Klp67A

Kif18

Kinesin-13 (MCAK)

?

Klp-7

KLP10A

Kif2A, 2B, MCAK

Kinesin-14 (NCD/Kar3)

Kar3

Kif2

Klp-3,15,16,17

Ncd

KifC1

Other Function

Kinesin-3 (Unc104)

Kif1

Kif14

Kinesin-10 (Nod)

Nod

Kid

Kinesin12 (Xklp2)

Klp-18


Normal text (viable), italicized text (not viable) differentiates the individual kinesin-isoform disruptions (knockout, knockdown, or mutation) and their effects on mitosis. The bold text for the kinesin-6 family members indicates cytokinesis defects. In this case, cells can proceed through one or more divisions, but longer term, the mutated protein is essential for organism viability. References for S.c [5], D.d[7-10, 12-14], C.e [39, 47-51], D.m [40], and H.s [15, 52].

Nag et al. BMC Cell Biology 2008 9:21   doi:10.1186/1471-2121-9-21

Open Data