Induction of ATM phosphorylation and H2AX phosphorylation by CS from different cigarettes. A549 cells were exposed under identical conditions to CS from IM16 reference research cigarette (FTC values of 15.7 mg "tar" and 1.01 mg nicotine), 2R4F reference research cigarette (FTC values of 9.7 mg "tar" and 0.85 mg nicotine), or Brand A (FTC values of 15 mg "tar" and 1.1 mg nicotine). The IM16, 2R4F reference cigarettes, and the Brand A commercial cigarette had essentially equivalent levels of ATM-A1981P and γH2AX IF.
Tanaka et al. BMC Cell Biology 2007 8:26 doi:10.1186/1471-2121-8-26