Marked reduction in the endosomal and nuclear localization of pSmad1 in Bmpr1aCKO lenses. A. WT (Cre-negative) lens; Rab5B (green), pSmad1 (red). B. Bmpr1aCKO (Cre-positive) lens Rab5B (green), pSmad1 (red). Both the number of endosomes and the relative number of Smad1-positive endosomes is reduced in the Bmpr1aCKO lens. In B, note the relative difference in staining intensity for pSmad1 and Rab5b in the ciliary epithelium (CE), compared to the Bmpr1aCKO lens.
Rajagopal et al. BMC Cell Biology 2007 8:25 doi:10.1186/1471-2121-8-25