A model summarizing the behavior of deletion mutants of Bax. The deletion constructs are named according to the beginning and end residue numbers. Different regions of Bax: N-terminal 29 residues, BH3 helix, the first and second helices of TM1 region (TM1.1 and TM1.2), BH2 helix and TM2 region, are color-coded as cyan, red, green, blue and purple, respectively. Constructs whose apoptotic activity is regulated by Bcl-xL are in shaded boxes. The open boxes show deletion mutants not regulated by Bcl-xL.
Parikh et al. BMC Cell Biology 2007 8:16 doi:10.1186/1471-2121-8-16