Comparison of the MEKK family: phylogenetic history and conserved domains. (A) Multiple sequence alignment of the MEKK family (including D-MEKK1a and D-MEKK1b, two alternatively-spliced variants of D-MEKK1 ) was done using Clustal X. Phylogeny was analyzed using Phylip and displayed using TreeView program. (B) Graphic representation of the selective divergence between the N-terminal regulatory domains and the C-terminal kinase domains of mammalian MEKKs from their Drosophila homologue D-MEKK1. Abbreviations (both A and B) are: Dm, Drosophila melanogaster, Hs, Homo sapiens, Mm, Mus musculus; PPP, proline-rich motif, PH, plekstrin homology motif, RB, Ras-binding motif, CRIB, cdc42/Rac-interactive binding motif.
Ryabinina et al. BMC Cell Biology 2006 7:7 doi:10.1186/1471-2121-7-7