Time-lapse imaging of thalidomide treated single EC tube structure. The tube was treated with 500 μmol SNP at 15th minute to find any further effect on the tube structure. No effect of either thalidomide or SNP was observed on the structure and morphology of the tube and the cells as well. However, thalidomide blocked the formation of filopodia, replacing them with broader protrusions on EC surface (arrows in the right panel).
Tamilarasan et al. BMC Cell Biology 2006 7:17 doi:10.1186/1471-2121-7-17