Inhibition of gap junctional communication in biopsied human gliomas. A. Vimentin immunostaining of the biopsied human glioblastoma HG-23 7 days after implantation into a cultured brain slice without (left panel) or with (right panel) CBX. Note the inhibition of cell migration when GJC is blocked. B, Connexin 43 immunocytochemistry (DAB, counterstained with hematoxylin) in two glioblastomas showing either moderate (HG-22) or abundant (HG-23) expression of the protein (×200). At the cellular level (inserts, ×1000), staining is dot-like or linear, predominantly at the membrane.
Oliveira et al. BMC Cell Biology 2005 6:7 doi:10.1186/1471-2121-6-7