Comparison of hybrid null-event MC and ODE models in terms of (a) dimerized EGFR in the absence of ligand at a high receptor density and diffusivity (11,000 per μm2, D = 2 × 10-14 m2sec-1) and assuming no initial dimers, and (b) EGF bound EGFR in the presence of ligand (160 nM) at low receptor density (125 per per μm2) and D = 2 × 10-15 m2sec-1. The reactions on the figure indicate the dominant processes responsible for the concentration trajectories. Error bars indicate 2 standard deviations obtained from 10 independent MC simulations.
Mayawala et al. BMC Cell Biology 2005 6:41 doi:10.1186/1471-2121-6-41