Figure 3.

Chic impairs nuclear export. Localization of GFP reporter appended with wild-type NLS and NES (B, D, F) or mutant NESP12 (A, C, E) in salivary gland cells. In wild-type (A) and chic mutants (C, E) NLS-NESP12-GFP is predominantly localized to the nucleus. In wild-type salivary glands NLS-NES+-GFP is mostly found in the cytoplasm (B). In contrast, in chic mutants, chic2/chic221 and chic01320 homozygotes, NLS-NES+-GFP is predominantly nuclear (D, F).

Minakhina et al. BMC Cell Biology 2005 6:32   doi:10.1186/1471-2121-6-32
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