Immunolocalization of APC and 5-HT2A in IEC-18 culture. A: APC immunostaining parallels that of C2 and is found in crypt cell strands but is absent or scant in adjacent cells. B-D: 5-HT2A immunostaining is absent in the majority of cells but is found in a few rare cells. On closer inspection, we found that there seemed to be a progressive increase in staining intensity that correlated with a morphologic transition away from IEC-18 cell morphology and towards that of a neuroendocrine-like cell (illustrated by the numbered circles).
Gordon et al. BMC Cell Biology 2005 6:2 doi:10.1186/1471-2121-6-2