Table 1

Effect of PBP10 on neutrophil NADPH-oxidase activity induced by receptor agonists#.

Neutrophil NADPH-oxidase activator (Concentration)

Neutrophil receptor(s)

Inhibition of NADPH-oxidase by PBP10 (1 μM)


WKYMVM (100 nM)

FPRL1

+

SAA (5 μM)

FPRL1

+

fMLF (100 nM)

FPR

-

Annexin9–25 (50 μM)

FPR

-

C5a (100 ng/ml)

C5aR

-

IL-8 (100 ng/ml)

CXCR1, CXCR2

-


Abbreviations: C5a, complement 5a; FPR, formyl peptide receptor; IL-8, interleukin 8; SAA, serum amyloid A.

Fu et al. BMC Cell Biology 2004 5:50   doi:10.1186/1471-2121-5-50

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