Figure 1.

Structure of lamin A protein.A) Diagram of lamin A amino acid sequence showing the domains of the protein, and the position of the four laminopathy-associated missense mutations in DCM, FPLD and AD-EDMD. B) Structure of the C-terminal globular domain of Lamin A showing the relative positions of the FPLD associated R482W missense mutation and the AD-EDMD associated L530P mutation. (Adapted with permission from [25]).