Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor β signaling
1 McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205, U.S.A
2 Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, DK-5230, Denmark
3 Department of Genome Informatics, Kazusa DNA Research Institute, Chiba 292-0812, Japan
4 Department of Pediatrics, National Jewish Medical and Research Center, Goodman Building, K1011, Denver, CO 80206, U.S.A
5 Ludwig Institute for Cancer Research, Uppsala, SE-751 24, Sweden
BMC Cell Biology 2004, 5:2 doi:10.1186/1471-2121-5-2Published: 19 January 2004
Transforming growth factor-βs (TGF-βs), bone morphogenetic proteins (BMPs) and activins are important regulators of developmental cell growth and differentiation. Signaling by these factors is mediated chiefly by the Smad family of latent transcription factors.
There are a large number of uncharacterized cDNA clones that code for novel proteins with homology to known signaling molecules. We have identified a novel molecule from the HUGE database that is related to a previously known molecule, AMSH (
This report implicates AMSH and AMSH-2 as a novel family of molecules that positively regulate the TGF-β signaling pathway. Our results suggest that this effect could be partially explained by AMSH-2 mediated decrease of the action of Smad7 on TGF-β signaling pathway.