Overexpression of TLK1B-KD results in missegregation of chromosomes and other mitotic abnormalities. a. A normal metaphase in MM3MG-KD cells. b. Multi-polar spindles frequently found in MM3MG-TLK1B-KD cells. c. Unequal segregation of chromosomes in MM3MG-TLK1B-KD cells. d. Persistence of microtubules from the mitotic spindle after metaphase. e. Persistence of microtubules after cytokinesis found frequently in MM3MG-TLK1B-KD cells. f. A representative metaphase chromosome spread with 84 chromosomes from an MM3MG-TLK1B-KD cell.
Sunavala-Dossabhoy et al. BMC Cell Biology 2003 4:16 doi:10.1186/1471-2121-4-16