Hypothesis
Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear
1 Brookdale Department of Molecular, Cell and Developmental Biology. Mount Sinai School of Medicine, New York, NY 10029-6574, USA
2 MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
BMC Cell Biology 2002, 3:28 doi:10.1186/1471-2121-3-28
Published: 25 November 2002Abstract
Background
Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel attachment to nonsensory cells, but the molecular components of the interface between gels and sensory cells remain to be identified.
Hypothesis
We report that the inner ear protein stereocilin is related in sequence to otoancorin and, based on its localisation and predicted GPI-anchoring, may mediate attachment of the tectorial and otoconial membranes to sensory hair bundles.
Testing
It is expected that antibodies directed against stereocilin would specifically label sites of contact between sensory hair cells and tectorial/otoconial membranes of the inner ear.
Implications
Our findings support a unified molecular mechanism for mechanotransduction, with stereocilin and otoancorin defining a new protein family responsible for the attachment of acellular gels to both sensory and nonsensory cells of the inner ear.
