References

  1. Harland RM: The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers [comment].

    Proc Natl Acad Sci U S A 1994, 91:10243-10246. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  2. Hogan BL: Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

    Genes Dev 1996, 10:1580-1594. PubMed Abstract OpenURL

  3. Kingsley DM: The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

    Genes Dev 1994, 8:133-146. PubMed Abstract OpenURL

  4. Reddi AH: Regulation of cartilage and bone differentiation by bone morphogenetic proteins.

    Curr Opin Cell Biol 1992, 4:850-855. PubMed Abstract OpenURL

  5. Kawabata M, Imamura T, Miyazono K: Signal transduction by bone morphogenetic proteins.

    Cytokine Growth Factor Rev 1998, 9:49-61. PubMed Abstract | Publisher Full Text OpenURL

  6. Massague J: TGF-beta signal transduction.

    Annu Rev Biochem 1998, 67:753-791. PubMed Abstract | Publisher Full Text OpenURL

  7. Wrana JL: Regulation of Smad activity.

    Cell 2000, 100:189-192. PubMed Abstract | Publisher Full Text OpenURL

  8. Zhang Y, Derynck R: Regulation of Smad signalling by protein associations and signalling crosstalk.

    Trends Cell Biol 1999, 9:274-279. PubMed Abstract | Publisher Full Text OpenURL

  9. Kawabata M, Inoue H, Hanyu A, Imamura T, Miyazono K: Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors.

    EMBO J 1998, 17:4056-4065. PubMed Abstract | Publisher Full Text OpenURL

  10. Massague J, Chen YG: Controlling TGF-beta signaling.

    Genes Dev 2000, 14:627-644. PubMed Abstract | Publisher Full Text OpenURL

  11. Attisano L, Wrana JL: Smads as transcriptional co-modulators.

    Curr Opin Cell Biol 2000, 12:235-243. PubMed Abstract | Publisher Full Text OpenURL

  12. Kim J, Johnson K, Chen HJ, Carroll S, Laughon A: Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic.

    Nature 1997, 388:304-308. PubMed Abstract | Publisher Full Text OpenURL

  13. de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, et al.: The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.

    J Biol Chem 2000, 275:2115-2122. PubMed Abstract | Publisher Full Text OpenURL

  14. Verschueren K, Remacle JE, Collart C, Kraft H, Baker BS, Tylzanowski P, et al.: SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.

    J Biol Chem 1999, 274:20489-20498. PubMed Abstract | Publisher Full Text OpenURL

  15. Shi X, Yang X, Chen D, Chang Z, Cao X: Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling.

    J Biol Chem 1999, 274:13711-13717. PubMed Abstract | Publisher Full Text OpenURL

  16. Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, et al.: Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300 [see comments].

    Science 1999, 284:479-482. PubMed Abstract | Publisher Full Text OpenURL

  17. Coux O, Tanaka K, Goldberg AL: Structure and functions of the 20S and 26S proteasomes.

    Annu Rev Biochem 1996, 65:801-847. PubMed Abstract | Publisher Full Text OpenURL

  18. Hayashi S, Murakami Y, Matsufuji S: Ornithine decarboxylase antizyme: a novel type of regulatory protein.

    Trends Biochem Sci 1996, 21:27-30. PubMed Abstract | Publisher Full Text OpenURL

  19. Chen P, Hochstrasser M: Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly.

    Cell 1996, 86:961-972. PubMed Abstract | Publisher Full Text OpenURL

  20. Pickart CM: Targeting of substrates to the 26S proteasome.

    FASEB J 1997, 11:1055-1066. PubMed Abstract OpenURL

  21. Tanaka K, Chiba T: The proteasome: a protein-destroying machine.

    Genes Cells 1998, 3:499-510. PubMed Abstract | Publisher Full Text OpenURL

  22. Cruz M, Nandi D, Hendil KB, Monaco JJ: Cloning and characterization of mouse Lmp3 cDNA, encoding a proteasome beta subunit.

    Gene 1997, 190:251-256. PubMed Abstract | Publisher Full Text OpenURL

  23. Kopp F, Kristensen P, Hendil KB, Johnsen A, Sobek A, Dahlmann B: The human proteasome subunit HsN3 is located in the inner rings of the complex dimer.

    J Mol Biol 1995, 248:264-272. PubMed Abstract | Publisher Full Text OpenURL

  24. Thomson S, Rivett AJ: Processing of N3, a mammalian proteasome beta-type subunit.

    Biochem J 1996, 315(Pt 3):733-738. PubMed Abstract | Publisher Full Text OpenURL

  25. Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, et al.: A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

    Genes Dev 2000, 14:1605-1616. PubMed Abstract | Publisher Full Text OpenURL

  26. Brent R, Finley RL Jr: Understanding gene and allele function with two-hybrid methods.

    Annu Rev Genet 1997, 31:663-704. PubMed Abstract | Publisher Full Text OpenURL

  27. Zervos AS, Gyuris J, Brent R: Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites [published erratum appears in Cell 1994 Oct 21;79(2):following 388].

    Cell 1993, 72:223-232. PubMed Abstract | Publisher Full Text OpenURL

  28. Ray R, Miller DM: Cloning and characterization of a human c-myc promoter-binding protein.

    Mol Cell Biol 1991, 11:2154-2161. PubMed Abstract OpenURL

  29. Gross B, Gaestel M, Bohm H, Bielka H: cDNA sequence coding for a translationally controlled human tumor protein.

    Nucleic Acids Res 1989, 17:8367. PubMed Abstract OpenURL

  30. Prosperi MT, Ferbus D, Karczinski I, Goubin G: A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins.

    J Biol Chem 1993, 268:11050-11056. PubMed Abstract | Publisher Full Text OpenURL

  31. Parks WT, Frank DB, Huff C, Renfrew HC, Martin J, Meng X, et al.: Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-beta Family of Receptor Serine-Threonine Kinases.

    J Biol Chem 2001, 276:19332-19339. PubMed Abstract | Publisher Full Text OpenURL

  32. Rousset R, Desbois C, Bantignies F, Jalinot P: Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome.

    Nature 1996, 381:328-331. PubMed Abstract | Publisher Full Text OpenURL

  33. Frentzel S, Pesold-Hurt B, Seelig A, Kloetzel PM: 20 S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13–16 S preproteasome complexes.

    J Mol Biol 1994, 236:975-981. PubMed Abstract | Publisher Full Text OpenURL

  34. Nandi D, Woodward E, Ginsburg DB, Monaco JJ: Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits.

    EMBO J 1997, 16:5363-5375. PubMed Abstract | Publisher Full Text OpenURL

  35. Schmidt M, Schmidtke G, Kloetzel PM: Structure and structure formation of the 20S proteasome.

    Mol Biol Rep 1997, 24:103-112. PubMed Abstract | Publisher Full Text OpenURL

  36. Schmidtke G, Schmidt M, Kloetzel PM: Maturation of mammalian 20 S proteasome: purification and characterization of 13 S and 16 S proteasome precursor complexes.

    J Mol Biol 1997, 268:95-106. PubMed Abstract | Publisher Full Text OpenURL

  37. Kruger E, Kloetzel P, Enenkel C: 20S proteasome biogenesis.

    Biochimie 2001, 83:289-293. PubMed Abstract | Publisher Full Text OpenURL

  38. Groll M, Ditzel L, Lowe J, Stock D, Bochtler M, Bartunik HD, et al.: Structure of 20S proteasome from yeast at 2.4 A resolution [see comments].

    Nature 1997, 386:463-471. PubMed Abstract | Publisher Full Text OpenURL

  39. Gruendler C, Lin Y, Farley J, Wang T: Proteasomal degradation of Smad1 induced by bone morphogenetic proteins.

    J Biol Chem 2001, 276:46533-46543. PubMed Abstract | Publisher Full Text OpenURL

  40. Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, et al.: MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

    Cell 1996, 85:489-500. PubMed Abstract | Publisher Full Text OpenURL

  41. Macias-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL: Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.

    J Biol Chem 1998, 273:25628-25636. PubMed Abstract | Publisher Full Text OpenURL

  42. Liu F, Hata A, Baker JC, Doody J, Carcamo J, Harland RM, et al.: A human Mad protein acting as a BMP-regulated transcriptional activator [see comments].

    Nature 1996, 381:620-623. PubMed Abstract | Publisher Full Text OpenURL

  43. Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, et al.: The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.

    Cell 1997, 89:1165-1173. PubMed Abstract | Publisher Full Text OpenURL

  44. Guo X, Lin Y, Horbinski C, Drahushuk KM, Kim I-J, Kaplan PL, Lein P, Wang T, Higgins D:

    J Neurobiology 2001, 48:120-130. Publisher Full Text OpenURL

  45. Matsufuji S, Inazawa J, Hayashi T, Miyazaki Y, Ichiba T, Furusaka A, et al.: Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization.

    Genomics 1996, 38:102-104. PubMed Abstract | Publisher Full Text OpenURL

  46. Ramos PC, Hockendorff J, Johnson ES, Varshavsky A, Dohmen RJ: Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.

    Cell 1998, 92:489-499. PubMed Abstract | Publisher Full Text OpenURL

  47. Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.

    Nature 1999, 400:687-693. PubMed Abstract | Publisher Full Text OpenURL

  48. Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K: Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein [see comments].

    Science 1999, 286:771-774. PubMed Abstract | Publisher Full Text OpenURL

  49. Sun Y, Liu X, Ng-Eaton E, Lodish HF, Weinberg RA: SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling.

    Proc Natl Acad Sci U S A 1999, 96:12442-12447. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  50. Lo RS, Massague J: Ubiquitin-dependent degradation of TGF-beta-activated Smad2.

    Nat Cell Biol 1999, 1:472-478. PubMed Abstract | Publisher Full Text OpenURL

  51. Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, et al.: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.

    J Biol Chem 2001, 276:12477-12480. PubMed Abstract | Publisher Full Text OpenURL

  52. Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, et al.: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.

    Mol Cell 2000, 6:1365-1375. PubMed Abstract | Publisher Full Text OpenURL

  53. Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R: Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.

    Proc Natl Acad Sci U S A 2001, 98:974-979. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  54. Lin X, Liang M, Feng XH: Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.

    J Biol Chem 2000, 275:36818-36822. PubMed Abstract | Publisher Full Text OpenURL

  55. Ausubel FM:

    In Current Protocols in Molecular Biology. (Edited by: Janssen K). New York: John Wiley & Sons; 1994, 1-20. OpenURL