Persistent MXD3 activation leads to decreased cell counts. Cell counts of (A) ER-MXD3, (B) ER-MXD3.E66D, and (C) DAOY cell lines over 7 days represented as fold change relative to initial seeding density. ER-MXD3 cell line significantly (p < 0.0001, two-way ANOVA, n = 6) responds to 4-OHT treatment compared to vehicle treatments. Whereas control ER-MXD3.E66D and DAOY lines are unaffected by 4-OHT treatment compared to vehicle treatments. Bonferroni post-test analysis results are noted with asterisks.
Ngo et al. BMC Cell Biology 2014 15:30 doi:10.1186/1471-2121-15-30