A comprehensive model for the dual action of GRASP and CNK3/IPCEF in promoting Arf to Rac crosstalk. GRASP and CNK3/IPCEF play distinct roles in bringing this multiprotein complex together. One of the scaffolds, CNK3/IPCEF recruits cytohesin 2 to the membrane in response to upstream signals (HGF) while the other, GRASP, binds both cytohesin 2 and Dock180 providing a physical bridge. Assembly of this complex promotes HGF-stimulated Rac activation and migration.
Attar and Santy BMC Cell Biology 2013 14:9 doi:10.1186/1471-2121-14-9