Table 1

p-values for PANTHER analysis of pathways, molecular function and biological processes of transcripts bound in (A) hNP1 and (B) hNP1 cells differentiated to neurons over 6 days (6dN)
A.
BORIS bound transcripts in hNP1 p-value
Pathway
WNT signaling pathway 33 0.00000258
Cadherin signaling pathway 23 0.00000012
Huntington disease 13 0.0252
Molecular function
binding 401 6.54E-18
nucleic acid binding 253 1.49E-14
DNA binding 164 2.39E-10
transcription factor activity 143 3.48E-09
transcription regulator activity 143 3.48E-09
RNA binding 48 7.86E-07
RNA splicing factor activity, transesterification mechanism 27 3.56E-05
helicase activity 19 5.85E-05
RNA helicase activity 13 1.73E-04
catalytic activity 263 9.25E-04
Biological process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 252 8.72E-15
metabolic process 422 3.19E-08
primary metabolic process 407 5.66E-08
cellular component organization 94 1.45E-05
protein transport 103 2.76E-05
intracellular protein transport 103 2.76E-05
organelle organization 29 1.74E-04
establishment or maintenance of chromatin architecture 27 2.42E-04
nervous system development 78 3.60E-04
vesicle-mediated transport 72 5.89E-04
B.
BORIS bound transcripts in 6dN p-value
Pathway
WNT signaling pathway 19 0.0325
Angiogenesis 16 0.00275
Inflammation mediated by chemokine and cytokine signaling pathway 15 0.115
Alzheimer disease-presenilin pathway 12 0.00257
TGF-beta signaling pathway 10 0.049
Molecular function
binding 315 1.05E-06
nucleic acid binding 191 1.76E-05
catalytic activity 245 1.26E-04
protein binding 156 1.39E-04
transferase activity, transferring glycosyl groups 22 1.67E-04
ubiquitin-protein ligase activity 29 2.83E-04
DNA binding 122 3.80E-04
transferase activity 85 6.67E-04
ligase activity 38 2.03E-03
RNA splicing factor activity, transesterification mechanism 20 3.28E-03
Biological process
cell cycle 114 7.90E-08
primary metabolic process 368 8.83E-08
metabolic process 376 4.35E-07
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 196 1.26E-06
protein transport 94 3.18E-05
intracellular protein transport 94 3.18E-05
protein metabolic process 162 5.45E-05
cellular process 284 5.66E-05
transport 145 7.51E-05
mitosis 41 6.49E-04

Ogunkolade et al.

Ogunkolade et al. BMC Cell Biology 2013 14:52   doi:10.1186/1471-2121-14-52

Open Data