Table 2

Protein annotation for biological processes of upregulated proteins
10 min/0 h 30 min/10 min 1 h/30 min 2 h/1 h
GO term #Seq Score GO term #Seq Score GO term #Seq Score GO term #Seq Score
Signaling 14 4,21 Signaling 31 8,92 Signaling 40 13,3 Developmental process 47 15
Cellular response to stimulus 19 5,67 Anatomical structure development 22 9,48 Multicellular organismal development 48 12,78 Signaling 17 4,13
Anatomical structure morphogenesis 13 4,21 Multicellular organismal development 8 2,39 Anatomical structure development 46 13,06 Anatomical structure development 41 12,3
Cell differentiation 18 5,95 Cell differentiation 6 2,48 Cell-cell signaling 9 2,96 Multicellular organismal development 43 8,57
Regulation of signaling 6 1,08 Cell surface receptor linked signaling pathway 3 2,6 Cell activation 7 3,18 Cell differentiation 20 9,36
Cell morphogenesis involved in differentiation 7 2,06 Cell morphogenesis involved in differentiation 30 5,77 System development 40 10,12 Cell surface receptor linked signaling pathway 9 3,63
Organ development 21 8 G-protein coupled receptor protein signaling pathway 4 3,2 Cell differentiation 33 15,09 Embryo development 7 3,14
Regulation of cell differentiation 6 1,12 Signal transduction 8 2,14 Cytoskeleton organization 26 9,55 System development 36 8,95
Signal transduction 11 5,73 Epithelial cell differentiation 13 6,01 Regulation of signaling 20 6,75 Cell development 15 5,97
Phosphorylation 14 4,67 Cell surface receptor linked signaling pathway 18 7,95 Cell morphogenesis involved in differentiation 9 2,47
Transmembrane receptor protein tyrosine kinase signaling pathway 4 2,56 Signal transduction 37 18,99 Organ development 26 10,7
Organ development 26 11,08 Regulation of signal transduction 6 2,1
Cell morphogenesis involved in differentiation 13 3,15 Signal transduction 17 6,54
Enzyme linked receptor protein signaling pathway 9 3,8 Epithelial cell differentiation 2 2
Intracellular protein kinase cascade 7 3,34 Regulation of gene expression 14 4,89
G-protein coupled receptor protein signaling pathway 6 4,77 Transmembrane receptor protein tyrosine kinase signaling pathway 5 2,92
Small GTPase mediated signal transduction 5 2,01 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 3 3
Second-messenger-mediated signaling 3 1,22 Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 4 4
Wnt receptor signaling pathway 3 1,08 Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 4 4
Phosphorylation 17 8,1 Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 4 4,8
Positive regulation of signal transduction 9 5,2
Transmembrane receptor protein tyrosine kinase signaling pathway 9 6,33
MAPKKK cascade 5 4
Negative regulation of cell proliferation 5 4,6
Positive regulation of intracellular protein kinase cascade 5 3
Negative regulation of cell cycle 4 1,84
Post-translational protein modification 4 4
Ras protein signal transduction 4 1,68
Regulation of Wnt receptor signaling pathway 3 1,56

Consistently upregulated proteins were input in Blast2go software for mapping and annotation of gene ontologies. Biological processes over-represented were selected and classified according to level. Top: low levels; bottom.

Halcsik et al.

Halcsik et al. BMC Cell Biology 2013 14:47   doi:10.1186/1471-2121-14-47

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