Figure 2.

Caspase-7 and-3 have distinct effects on ROS production during apoptosis. (A) Expression levels of effector caspases in Casp KO MEFs were determined by western blot. (B) WT, Casp7-/-, Casp3-/- and Casp3-/-7-/- MEFs were withdrawn from serum for 12 hr. ROS production was determined by flow cytometry. Treatment with 50 μg/ml antimycin A for 30 min was used as a positive control. Data are representative of at least 3 independent experiments.

Brentnall et al. BMC Cell Biology 2013 14:32   doi:10.1186/1471-2121-14-32
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