Open Access Research article

Lentivirus-mediated RNA interference targeting the H19 gene inhibits cell proliferation and apoptosis in human choriocarcinoma cell line JAR

Li-Li Yu1, Kai Chang1, Lin-Shan Lu1, Dan Zhao1, Jian Han1, Ying-Ru Zheng1, Yao-Hua Yan1, Ping Yi1, Jian-Xin Guo1, Yuan-Guo Zhou2, Ming Chen1* and Li Li1*

Author Affiliations

1 Department of Obstetrics and Gynecology, Daping Hospital, The Third Military Medical University, Chongqing 400042, China

2 Molecular Biology Center, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, China

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BMC Cell Biology 2013, 14:26  doi:10.1186/1471-2121-14-26

Published: 27 May 2013

Additional files

Additional file 1: Table S1:

The structure of siRNAs in lentiviral vectors. Table S2 The Ct values from quantitative PCR reactions. Figure S1: Effect of H19 knockdown on the invasion of JAR cells. The invasion rate of cells in the H19 knockdown group and the NC group were 68.85% ± 3.04% and 79.50% ± 5.52%, respectively. H19 knockdown had no significant impact on the invasion rate of JAR cells.

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