Table 4

MPs levels in the plasma and body fluids of patients with different disorders
Disease MPs plasma levels Reference
AUTOIMMUNE DISEASES
Ankylosing spondylitis No differences between patient and control groups in EMPs and PMPs levels Sari et al., 2012
Anti-phospholipid syndrome Elevated MPs levels; TF+ EMPs, monocyte-derived MPs Joseph et al., 2001; Dignat-George et al., 2004; Jy et al., 2007; Vikerfors et al., 2012
Arthritis Elevated MPs levels Berckmans et al., 2002; Boilard et al., 2010
Acute inflammatory bowel disease Elevated MPs levels; elevated TF+ MPs Andoh et al., 2005; Palkovits et al., 2012
Behcet’s disease (systemic vasculitis) CD62+-MPs levels elevated Macey et al., 2011
Cirrhosis Elevated CD31+/41-; CD11a+; CD4+; CD235a+; cytokeratin 18+ MPs Rautou et al., 2012
Crohn’s disease Elevated MPs levels comparing with normal and ulcerative colitis Chamouard et al., 2005
Diabetes mellitus Different patterns of MPs, PMPs na MMPs levels and also differences from diabetes type II pattern Diamant et al., 2002; Sabatier et al., 2002; Shouzu et al., 2004; Ogata et al., 2005 Tramontano et al., 2010
Diabetic retinopathy Increased vitreous shedding of MPs, endothelial,platelet, photoreceptor, and microglial origin Ogata et al., 2005; 2006; Chahed et al., 2010
Diabetes type II (Diabetes mellitus) Elevated MPs levels; Nomura et al., 1995; Sabatier et al., 2002; Nomura et al., 2004b; Tan et al., 2005; Jung et al., 2009a; Koga et al., 2005; 2006; Leroyer et al., 2008; Nomura, 2009; Nomura et al. 2009; Bernard et al., 2009; Tsimerman et al., 2011; Nomura et al., 2011
AnnexinV++ MPs elevated
Kawasaki disease Elevated MPs levels, especially EC and T-cells derived Guiducci et al., 2011; Tan et al., 2012
Mixed connective tissue disease Elevated PMPs levels Oyabu et al., 2011
Multiple sclerosis Elevated MPs and PMPs levels Larkin, 2001; Minagar et al., 2001; Jy et al., 2004; Jimenez et al., 2005; Sheremata et al., 2006; 2008
Polymyositis/dermatomyositis Elevated MPs and B-lymphocyte–derived MPs levels Shirafuji et al., 2009; Baka et al., 2010
Psoriasis Elevated PMPs levels Tamagawa-Mineoka et al., 2010; Pelletier et al., 2011
Rheumatoid arthritis Different patterns of MPs levels in plasma; increased PMPs expressing activating markers; increased MPs in synovial fluid; increased MPs exposing complement components (C1q, serum amyloid-P) Joseph et al., 2001; Knijff-Dutmer et al., 2002; Berckmans et al., 2002; Biro et al., 2007; Sellam et al., 2009; Messer et al., 2009; Umekita et al., 2009; van Eijk et al., 2010
Sjorgen syndrome Elevated MPs, PMPs, leukocyte-derived MPs levels Sellam et al., 2009
Systemic lupus erythematosus Elevated MPs levels; PMPs levels; Combes et al., 1999; Joseph et al., 2001; Nagahama et al., 2001; Pereira et al., 2006; Sellam et al., 2009; Antwi-Baffour et al., 2010; Nielsen et al., 2011; 2012;
Elevated levels of Annexin V-negative MPs;
Elevated annexin V+ CD31+ EMPs; elevated levels of MPs with increased loads of IgG, IgM and C1q
Systemic sclerosis Elevated MPs and PMPs levels Guiducci et al., 2008; Nomura et al., 2008; Oyabu et al., 2011
Vasculitis Elevated MPs levels Brogan et al., 2004; Daniel et al., 2006; Erdbruegger et al., 2008
BLOOD DISORDERS
Aplastic anemia Elevated procoagulant MPs Hugel et al., 1999
Beta-thallasemia Elevated MPs levels; elevated annexin V+ MPs from plathelets and red blood cells Pattanapanyasat et al., 2004; 2007; Habib et al., 2008; Chaichompoo et al., 2012
Disseminated intravascular coagulation (DIC) Elevated MPs Rahman et al., 2011
Essential thrombocytemia Elevated PMPs and EMPs levels Trappenburg et al., 2009
Haemophilia Elevated MPs levels Proulle et al., 2005
Henoch-Schönlein purpura (HSP) Elevated EMPs levels Dursun et al., 2010
Immune thrombocytopenic purpura (ITP) Elevated MPs levels in acute phase and decreased in chronic phase; increased Er-Mps and PMPs levels Jy, 1992;Tantawy et al., 2009; Sewify et al., 2013
Paroxysmal nocturnal hemoglobinuria Elevated MPs and EMPs levels Hugel et al., 1999; Liebman, Feinsten, 2003; Simak et al., 2004; Helley et al., 2010
Scott’s syndrome, Castaman syndrome, Glanzmann thromboasthenia (bleeding disorders) MPs deficiency Sims et al., 1989; Gemmel et al., 1993; Castaman et al., 1996; Toti et al., 1996
Sickle cell anemia Elevated MPs levels; increased annexin V and PS-MPs levels, increased TF+-MPs; elevated Er-MPs Shet et al., 2003; van Tits et al., 2009; van Beers et al., 2009; Gerotziafas et al., 2012
Thrombotic thrombocytopenic purpura Elevated MPs and PMPs levels Galli et al., 1996; Jimenez et al., 2001
CARDIOVASCULAR DISEASES
Acute coronary syndrome Elevated EMPs levels; Bernal-Mizrahi et al., 2003; Biassuci et al., 2012
Elevated Annexin V+, EMPs and PMPs levels
Acute pulmonary embolism PMPs elevated Bal et al., 2010
Arterial erectile dysfunction Elevated EMPs levels La Vignera et al., 2012; Condorelli et al., 2012
Cardiomyopathy Elevated MPs, MMPs levels; decreased endothelial MPs levels Walenta et al., 2012
Cardiopulmonary resuscitation Elevated Annexin V+-MPs Fink et al., 2011
Cerebrovascular accidents Elevated MPs levels; EMPs, PMPs elevated in patients with subarachnoid hemorrhage and acute cerebral infarction Lee et al., 1993; Jung et al., 2009b; Lackner et al., 2010; Kuriyama et al., 2010
Chronic venous unsufficiency Elevated EMPs and PMPs levels Georgescu et al., 2009
Coronary artery disease CD31+, Annexin V+ MPs increased Werner et al., 2006; Amabile et al., 2011
Hypertension Elevated eMPs Preston et al., 2003; Huang et al., 2010
Myocardial infarction Elevated MPs and PMPs levels Stepien et al., 2012
Non-valvular atrial fibrillation PMPs elevated Choudhury et al., 2007
Pulmonary hypertension Elevated CD62+ EMPs, leukocyte-derived MPs Amabile et al., 2008, 2009; Bakouboula et al., 2008
Thromboangiitis obliterans (Buerger’s disease) Elevated MPs during exacerebration Damige et al., 2010
Valvular atrial fibrillation CD41+ PMPs elevated Azzam, Zagloul, 2009
Vasculites associated with anti-neutrophil antibodies (Wegener’s granulomatosis; Churg-Strauss syndrome; microscopic polyangiitis) PMPs, NMPs and EMPs elevated Brogan et al., 2004; Daniel et al., 2006; Erdbruegger et al., 2008; Kuempers et al., 2008
Deep vein thrombosis MPs levels are not increased Steppich et al., 2011
Venous thromboembolism Elevated EMPs Chirinos et al., 2005
Unstable angina, Cardiovascular disease, arteriosclerosis obliterans, atherosclerosis, ischemic stroke Elevated MPs and PMPs levels; Singh N, 1995; Mallat et al., 2001; Nomura et al., 2004a; Dymicka-Piekarska et al., 2005; Zielinska et al., 2005; Morel et al., 2005; Simak et al., 2006; Michelsen et al., 2009; Kim et al., 2012
Elevated CD105+ (mesenchymal stem cell marker) after stroke, especially extensive ischemic stroke
INFECTIOUS DISEASES
Hepatitis C Elevated T-cell MPs levels correlated with severity of disease Kornek et al., 2011, 2012
Hepatitis C with cirrhosis Elevated MPs levels comparing with HepC; elevated MPs from CD4+ and CD8+ T-cells Brodsky et al., 2008
HIV Elevated MPs and EMPs levels; upregulation TF and P-selectin Gris et al., 1996; Holme et al., 1998; Corrales-Medina et al., 2010; da Silva et al., 2011; Mayne et al., 2011
Hemolytic uremic syndrome (enterohemorrhagic Escherichia coli infection) Elevated PMPs and MMPs levels Stahl et al., 2009; 2011
Plasmodium falciparum and P. vivax infections Elevated MPs levels, Er-MPs levels Combes, 2004; 2005; Campos et al., 2010; Pankoui Mfonkeu et al., 2010; Nantakomol et al., 2011
Sepsis (menningococcal) Elevated procoagulant MPs levels Niewland et al., 2000
Sepsis (Streptococcus pyogenes) Elevated PS+-MPs levels Oehmcke et al., 2011
Sepsis (pneumococcus, enterococcus, staphylococcus-associated) Elevated endothelial protein C-receptor+-MPs Perez-Casal et al., 2011
Sepsis and trauma Different patterns of MPs levels Joop et al., 2001; Ogura et al., 2001; Fujimi et al., 2003; Morel et al., 2008; Mostefai et al., 2008; Park et al., 2012
Sepsis (Candida albicans) Elevated CD42a+ and PAC1+ PMPs Woth et al., 2012
Shiga-toxin induced haemolytic Elevated MPs (platelets, monocytes, granulocytes) Ge et al., 2012
uraemic syndrome (HUS)
Systemic Inflammatory Response syndrome (SIRS) Elevated MPs levels Ogura et al., 2004
FEMALE DISORDERS
Polycystic ovary syndrome (PCOS) Elevated pMPs levels in women with PCOS and hyperandrogenemia Koiou et al., 2011; 2013
Pre-eclampsia and eclampsia Different patterns of MPs levels compared with normal pregnancies; endothelial CD41- MPs elevated; CD62+ MPs elevated; MMPs and CD8+ and granulocyte-derived MPs elevated VanWijk et al., 2002; Goswami et al., 2006; Lok et al., 2008; 2009; Macey et al., 2010; Reyna-Villasmil et al., 2011; Alijotas-Reig et al., 2012
Pathological pregnancies PMPs levels decreased comparing with normal pregnancies Bretelle et al., 2003; Carp et al., 2004
Postmenopausal women taking hormone replacement therapy Elevated MPs from platelets/megakaryocytes (CD61+) Rank et al., 2012
KIDNEY DISORDERS
Chronic renal failure CD144+ and CD146+ EMPs elevated Amabile et al., 2005; Faure et al., 2006
Different nephropathies (nephrosclerosis; lupus nephropathy; diabetic nephropathy) MPs levels are not changed Daniel et al., 2006
Hemodyalisis Elevated MPs Daniel et al., 2006
Nephrotic syndrome Lactahedrin+ ErMPs, PMPs and EMPs elevated Gao et al., 2012
Uremia with or w/o dialysis Elevated MPs, EMPs levels Nomura et al., 1993; Merino et al., 2010
TRANSPLANTATION
GVHD disease (allogeneic hematopoietic stem cell transplantation) Elevated MPs, PMPs levels; Pihusch et al., 2002; Nomura et al., 2005; 2008; Trummer et al., 2011; Rank et al., 2011; De Rop et al., 2011; Wu et al., 2012
Elevated PSGL-1 MPs levels
Elevated Er-MPs levels
Elevated EMPs levels; decreased EMPs in early phase after allo-HSCT
Kidney transplantation Procoagulant MPs decreased Al-Massarani et al., 2009
Liver transplantation Elevated MPs levels Brodsky et al., 2008
OTHER
Acute liver injury Elevated CD39+ MPs levels Schmelzle et al., 2012
Acute respiratory distress syndrome Elevated Leu and NeuMPs levels Guervilly et al., 2011
Alzheimer’s disease Elevated EMPs Xue et al., 2012
Atopic dermatitis Elevated PMPs levels Tamagawa-Mineoka et al., 2009
Cystic fibrosis Elevated levels of granulocyte MPs in sputum (CD11a+ and CD66b+) Porro et al., 2010
Fabry disease Elevated CD63+ MPs Gelderman et al., 2007; Vedder et al., 2009
Metabolic syndrome Different patterns of MPs levels : Arteaga et al., 2006; Chironi et al., 2006; Agouni et al., 2008; Ueba et al., 2008; Helal et al., 2010
Elevated EMPs, PMPs, leukocyte-derived MPs and Er-MPs levels
Obstructive sleep apnea syndrome PMPs elevated Maruyama et al., 2012
Polymyalgia rheumatica CD31+/CD42- EMPs elevated Pirro et al., 2011
Schizophrenia MPs elevated in cerebrospinal liquid Mobarrez et al., 2013

*references for Table 4 (Additional file 7).

Barteneva et al.

Barteneva et al. BMC Cell Biology 2013 14:23   doi:10.1186/1471-2121-14-23

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