ceMTM3 knockdown-induced loss of muscle fibers is accompanied by shortening of body size in aged C. elegans worms. Normal N2 worms were cultured on NGM plates containing E. coli cells carrying vector control or ceMTM3 RNAi from the time they were hatched from eggs. A. Photography of typical worms at day 3, day 5, and day 7. B. Statistical comparison of body length of worms. Data represents mean ± SD (n≥12). ** p < 0.01. C. Revelation of muscle cells and muscle fibers by Alexa Fluor 568 phalloidin staining of day 5 worms. D. Statistical comparison of muscle size of worms. Data represents mean ± SD (n≥14). *** p < 0.001.
Yu et al. BMC Cell Biology 2012 13:28 doi:10.1186/1471-2121-13-28