Regulatory pathways in the regulation of ROCK1 and cell migration in HD matrix. HD matrix inhibits Notch1 via HDAC(s) leading to upregulation of ROCK1 transcript, protein and activity levels. ROCK1 in turn increases cell contractility and together with matrix proteolysis, facilitate cell migration into HD matrix.
Raviraj et al. BMC Cell Biology 2012 13:12 doi:10.1186/1471-2121-13-12